<p>This family includes metal-fist type transcriptional repressors of copper transport systems such as copYZAB of <taxon tax_id="1354">Enterococcus hirae</taxon> and tcrYAZB (transferable copper resistance) of an <taxon tax_id="1352">Enterococcus faecium</taxon> (Streptococcus faecium) plasmid. High levels of copper can displace zinc and prevent binding by the repressor, activating efflux by copper resistance transporters. The most closely related proteins excluded by this entry are antibiotic resistance regulators including the methicillin resistance regulatory protein MecI.</p> Copper transport repressor CopY/TcrY